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GHK-Cu

Technical Monograph

GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a naturally occurring copper complex. It is a powerful biochemical modulator investigated for its role in extracellular matrix remodeling, angiogenesis, and nerve outgrowth.

Mechanism of Action

GHK-Cu regulates the expression of thousands of genes. It upregulates the synthesis of collagen, elastin, and glycosaminoglycans via fibroblast activation, whilst simultaneously modulating the expression of matrix metalloproteinases (MMPs) to facilitate ECM remodeling.

Pharmacological Detail

Acts as a carrier peptide to facilitate copper delivery to intracellular environments essential for the function of enzymes like lysyl oxidase (collagen cross-linking) and superoxide dismutase (antioxidant).

Pharmacodynamics

Stimulates tissue remodeling pathways, promoting angiogenesis and cellular proliferation in areas of tissue damage.

Pharmacokinetics

Highly localized activity in cutaneous models. Systemic models demonstrate rapid clearance and tissue uptake.

Preclinical Observations & In Vitro Data

Extensively researched in the context of wound healing, chronic inflammation, and aesthetic dermatology. Data cited from published literature.

Gene Expression Pilot (In Vitro): Reversed expression of 84 genes associated with metastasis.
Dermal Density Study (Clinical): Increased skin thickness and elasticity markers documented.

Abstract Highlights

  • Epigenetic modulation of over 4,000 human genes
  • Upregulation of Type I and III collagen synthesis
  • Nerve outgrowth and neuroprotective pathway signaling
  • Significant anti-inflammatory activity documented via TGF-beta suppression

Chemical Specifications

404.9 g/mol
C14H24N6O4Cu

Material Handling & Stability

Laboratory StorageLyophilized powder is stable at room temperature but optimally stored at 4°C.
Aqueous StabilityExtremely stable. Reconstituted solutions maintain integrity for up to 30 days at 2-8°C.

Strict Notice

THIS COMPOUND IS PRODUCED FOR LABORATORY RESEARCH PURPOSES ONLY. NOT FOR HUMAN CONSUMPTION. MATERIAL DATA SHEETS AND LABORATORY GUIDELINES SHOULD BE CONSULTED PRIOR TO HANDLING.