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HGH Frag 176-191

Technical Monograph

HGH Fragment 176-191 is an unmodified synthetic lipolytic isolated sequence extracted from the C-terminal tail of human growth hormone. Functionally analogous to AOD-9604 but lacking the protective tyrosine cap, it represents the exact endogenous sequence responsible for the lipid-oxidizing behavior associated with somatotropin administration.

Mechanism of Action

Fragment 176-191 interacts functionally with beta-3 adrenergic receptors in white and brown adipose tissues. It signals strictly for intracellular cyclic AMP (cAMP) escalation, which directly provokes the phosphorylation of hormone-sensitive lipase (HSL) and perilipin.

Pharmacological Detail

Directly interrupts the metabolic stabilization of adipocytes, favoring constant FFA liberation specifically under fasted states.

Pharmacodynamics

Intensely upregulates energy substrate liberation. Cannot alter IGF-1 transcription.

Pharmacokinetics

Highly unstable half-life in peripheral circulation (15-30 minutes). Rapidly degraded by widespread serum peptidases.

Preclinical Observations & In Vitro Data

Highly researched in early 2000s lipolytic development pathways. Despite rapid serum disappearance, single properly timed doses establish lipolytic cascades persisting significantly longer than the peptide's elimination boundary.

In Vitro (Adipocytes): Stimulated lipolysis and inhibited specifically lipogenesis in primary adipocyte cultures.

Observed Timeline of Action

TimeframePharmacological Effect
30-60 minsPeak FFA blood concentration following correctly fasted administration.
Day 7Upregulation of resting localized fat oxidation parameters measurable.

Abstract Highlights

  • Matches specific activity of intact hGH regarding pure lipid oxidation
  • Causes up to 12.5 times higher lipolysis rate in vivo compared to whole continuous GH
  • Exhibits specific lipolytic targeting of notoriously stable visceral fat deposits

References

Wu Z, et al. (1993)."Influence of human growth hormone fragment 177-191 on glucose metabolism."Endocrinology.

Chemical Specifications

1817.1 g/mol
C78H125N23O23S2
Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe

Material Handling & Stability

Laboratory StorageLyophilized powder: Deep freeze (-20°C to -80°C).
Aqueous StabilityReconstituted: Very short workable lifespan. Store strictly at 2-8°C.

Strict Notice

THIS COMPOUND IS PRODUCED FOR LABORATORY RESEARCH PURPOSES ONLY. NOT FOR HUMAN CONSUMPTION. MATERIAL DATA SHEETS AND LABORATORY GUIDELINES SHOULD BE CONSULTED PRIOR TO HANDLING.