Kisspeptin-10
Technical Monograph
Kisspeptin-10 is a potent neo-functional peptide derived from the KISS1 gene product. It functions as the master upstream regulator of the hypothalamic-pituitary-gonadal (HPG) axis.
Mechanism of Action
Kisspeptin binds exclusively to the G-protein coupled receptor GPR54 (KISS1R) located directly on GnRH neurons. This induces profound, pulsatile release of Gonadotropin-Releasing Hormone, initiating the hormonal cascade for testosterone and estrogen production.
Pharmacological Detail
Direct target activation on GnRH neurons ensures highly physiological hormonal output compared to exogenous androgen therapy, preserving intrinsic axis function.
Pharmacodynamics
Induces intense, transient spikes in LH and FSH following application, strongly correlating with subsequent gonadal steroidogenesis.
Pharmacokinetics
Kisspeptin-10 has a very rapid half-life (< 10 minutes). However, the resulting endocrine cascade persists for several hours.
Preclinical Observations & In Vitro Data
Extensively researched in the context of reproductive endocrinology, hypogonadism, and ovulation induction. Data cited from published literature.
Abstract Highlights
- Master upstream regulation of the HPG axis
- Robust stimulation of LH and FSH release observed
- Does not trigger negative feedback inhibition via the pituitary
- Investigation into fertility and metabolic implications
Chemical Specifications
Material Handling & Stability
Strict Notice
THIS COMPOUND IS PRODUCED FOR LABORATORY RESEARCH PURPOSES ONLY. NOT FOR HUMAN CONSUMPTION. MATERIAL DATA SHEETS AND LABORATORY GUIDELINES SHOULD BE CONSULTED PRIOR TO HANDLING.