MOTS-c
Technical Monograph
MOTS-c (Mitochondrial open reading frame of the 12S rRNA-c) is a mitochondrial-derived peptide. It acts as a signaling hormone linking mitochondrial function with systemic metabolic regulation.
Mechanism of Action
MOTS-c translocates to the nucleus to regulate gene expression via the AMPK pathway. It mimics the effects of exercise by upregulating skeletal muscle metabolism and improving cellular energy efficiency.
Pharmacological Detail
Targets the skeletal muscle, functioning via the folate-purine-AMPK pathway. It enhances cellular sensitivity to insulin entirely independent of the insulin receptor pathway.
Pharmacodynamics
Activates metabolic pathways identical to those stimulated by intense aerobic exertion, driving fatty acid oxidation and glucose uptake.
Pharmacokinetics
Requires localized or systemic introduction. In vivo models show peak metabolic pathway activation within hours.
Preclinical Observations & In Vitro Data
Significant research focus in the fields of aging and metabolic disorders. Preclinical data indicates prevention of diet-induced obesity. Data cited from published literature.
Abstract Highlights
- AMPK pathway activation documented
- Improved glucose utilization in skeletal muscle cells
- Mitochondrial-nuclear signaling axis regulation
- Investigation into age-related metabolic decline prevention
Chemical Specifications
Material Handling & Stability
Strict Notice
THIS COMPOUND IS PRODUCED FOR LABORATORY RESEARCH PURPOSES ONLY. NOT FOR HUMAN CONSUMPTION. MATERIAL DATA SHEETS AND LABORATORY GUIDELINES SHOULD BE CONSULTED PRIOR TO HANDLING.